Larsen Syndrome and Associated Spinal Deformities

نویسندگان

چکیده

Larsen syndrome is a rare genetic disorder that affects the connective tissue within body. The present narrative review aims to examine basis of syndrome, clarify its symptoms, and define all existing therapeutic approaches. A comprehensive search was performed in PubMed database. Inclusion criteria considered molecular clinical studies, management surgical treatment related deformities, case reports patients with reviews associated anomalies, articles whose full text available PubMed, published English language. caused by mutations FLNB gene, which encodes cytoskeletal protein filamin B, crucial development skeleton. Symptoms include joint dislocations, characteristic facial features anomalies spine. may be conservatively treated initially, although intervention usually required. Various techniques, including posterior spinal fusion, anterior decompression, circumferential arthrodesis, single-stage 360° fixation, have been proposed along growth-sparing procedures. Preoperative postoperative care education ensure optimal results. Further research needed identify novel modalities for this condition.

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ژورنال

عنوان ژورنال: Cureus

سال: 2023

ISSN: ['2168-8184']

DOI: https://doi.org/10.7759/cureus.41655